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Abstract Neutrinoless double-beta decay ( $0\nu \beta \beta$) is a rare nuclear process that, if observed, will provide insight into the nature of neutrinos and help explain the matter-antimatter asymmetry in the Universe. The large enriched germanium experiment for neutrinoless double-beta decay (LEGEND) will operate in two phases to search for $0\nu \beta \beta$. The first (second) stage will employ 200 (1000) kg of High-Purity Germanium (HPGe) enriched in⁷⁶Ge to achieve a half-life sensitivity of 10²⁷(10²⁸) years. In this study, we present a semi-supervised data-driven approach to remove non-physical events captured by HPGe detectors powered by a novel artificial intelligence model. We utilize affinity propagation to cluster waveform signals based on their shape and a support vector machine to classify them into different categories. We train, optimize, and test our model on data taken from a natural abundance HPGe detector installed in the Full Chain Test experimental stand at the University of North Carolina at Chapel Hill. We demonstrate that our model yields a maximum sacrifice of physics events of ${0.024}_{-0.003}^{+0.004}\mathrm{\%}$after data cleaning. Our model is being used to accelerate data cleaning development for LEGEND-200 and will serve to improve data cleaning procedures for LEGEND-1000. 

$\text{DMRadio-}{\mathrm{m}}^3$is an experimental search for dark matter axions. It uses a solenoidal dc magnetic field to convert an axion dark-matter signal to an ac electromagnetic response in a coaxial copper pickup. The current induced by this axion signal is measured by dc SQUIDs. $\text{DMRadio-}{\mathrm{m}}^3$is designed to be sensitive to Kim-Shifman-Vainshtein-Zakharov (KSVZ) and Dine-Fischler-Srednicki-Zhitnisky (DFSZ) QCD axion models in the 10–200 MHz ( $41\mathrm{neV}/c^2–0.83\mathrm{\mu }\mathrm{eV}/c^2$) range, and to axions with $g_{a\gamma \gamma }=g_{a\gamma \gamma ,\mathrm{DFSZ}}\left(30\mathrm{MHz}\right)=1.87\times {10}^{-17}{\mathrm{GeV}}^{-1}$over 5–30 MHz as an extended goal. In this work, we present the electromagnetic modeling of the response of the experiment to an axion signal over the full frequency range of $\text{DMRadio-}{\mathrm{m}}^3$, which extends from the low-frequency, lumped-element limit to a regime where the axion Compton wavelength is only a factor of 2 larger than the detector size. With these results, we determine the live time and sensitivity of the experiment. The primary science goal of sensitivity to DFSZ axions across 30–200 MHz can be achieved with a $3\sigma$live scan time of 2.9 years. 

76Ge can ββ decay into three possible excited states of 76Se, with the emission of two or, if the neutrino is Majorana, zero neutrinos. None of these six transitions have yet been observed. The Majorana Demonstrator was designed to study ββ decay of 76Ge using a low background array of high purity germanium detectors. With 98.2 kg-y of isotopic exposure, the Demonstrator sets the strongest half-life limits to date for all six transition modes. For 2νββ to the 0+ state of 76Se, this search has begun to probe for the first time half-life values predicted using modern many-body nuclear theory techniques, setting a limit of T_1/2 > 1.5e24 y (90% CL). 

Abstract Serial x-ray crystallography can uncover binding events, and subsequent chemical conversions occurring during enzymatic reaction. Here, we reveal the structure, binding and cleavage of moxalactam antibiotic bound to L1 metallo-β-lactamase (MBL) from Stenotrophomonas maltophilia . Using time-resolved serial synchrotron crystallography, we show the time course of β-lactam hydrolysis and determine ten snapshots (20, 40, 60, 80, 100, 150, 300, 500, 2000 and 4000 ms) at 2.20 Å resolution. The reaction is initiated by laser pulse releasing Zn 2+ ions from a UV-labile photocage. Two metal ions bind to the active site, followed by binding of moxalactam and the intact β-lactam ring is observed for 100 ms after photolysis. Cleavage of β-lactam is detected at 150 ms and the ligand is significantly displaced. The reaction product adjusts its conformation reaching steady state at 2000 ms corresponding to the relaxed state of the enzyme. Only small changes are observed in the positions of Zn 2+ ions and the active site residues. Mechanistic details captured here can be generalized to other MBLs. 

Charge conservation and the Pauli exclusion principle result from fundamental symmetries in the standard model of particle physics, and are typically taken as axiomatic. High-precision tests for small violations of these symmetries could point to new physics. Here we consider three models for violation of these processes, which would produce detectable ionization in the high-purity germanium detectors of the MAJORANA DEMONSTRATOR experiment. Using a 37.5 kg yr exposure, we report a lower limit on the electron mean lifetime, improving the previous best limit for the e->nununu decay channel by more than an order of magnitude. We also present searches for two types of violation of the Pauli exclusion principle, setting limits on the probability of an electron to be found in a symmetric quantum state. 

Abstract TheMajorana Demonstratorwas a search for neutrinoless double-beta decay (0νββ) in the⁷⁶Ge isotope. It was staged at the 4850-foot level of the Sanford Underground Research Facility (SURF) in Lead, SD. The experiment consisted of 58 germanium detectors housed in a low background shield and was calibrated once per week by deploying a²²⁸Th line source for 1 to 2 hours. The energy scale calibration determination for the detector array was automated using custom analysis tools. We describe the offline procedure for calibration of theDemonstratorgermanium detectors, including the simultaneous fitting of multiple spectral peaks, estimation of energy scale uncertainties, and the automation of the calibration procedure. 

With excellent energy resolution and ultralow-level radiogenic backgrounds, the high-purity germanium detectors in the Majorana Demonstrator enable searches for several classes of exotic dark matter (DM) models. In this work, we report new experimental limits on keV-scale sterile neutrino DM via the transition magnetic moment from conversion to active neutrinos 𝜈𝑠→𝜈𝑎. We report new limits on fermionic dark matter absorption (𝜒+𝐴→𝜈+𝐴) and sub-GeV DM-nucleus 3→2 scattering (𝜒+𝜒+𝐴→𝜙+𝐴), and new exclusion limits for bosonic dark matter (axionlike particles and dark photons). These searches utilize the (1–100)-keV low-energy region of a 37.5-kg y exposure collected by the Demonstrator between May 2016 and November 2019 using a set of 76Ge-enriched detectors whose surface exposure time was carefully controlled, resulting in extremely low levels of cosmogenic activation.